| Function: | Antiparasitic |
|---|---|
| Certification: | GMP |
| Grade Standard: | Medicine Grade |
| Type: | Chemical Reagent |
| State: | Solid |
| Volatile: | Not Volatile |
| Samples: |
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| Customization: |
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| Product Name | Selamectin | |
boiling point |
299.0±36.0 °C | |
density |
1.19±0.1 g/cm3 | |
| storage | Sealed in dry,Room Temperature | |
| Valid time | 2 YEAR | |
| Package | 10kg/Bottle, 20kg/Drum |
Description:
01.Seramectin (also known as seramectin) is produced by the fermentation of a new strain of Streptomyces aviviae, which is genetically modified by Pfizer in the United States. It is obtained by chemically synthesizing and structurally modifying Dolamectin. It was first released in the United Kingdom in July 1999 under the brand name Revolution.
02.The mechanism of action of seramectin is the same as that of other abamectin drugs. On the one hand, seramectin can act as a gamma-aminobutyric acid (GABA) agonist to trigger the release of presynaptic GABA, which leads to the increase of membrane permeability to Cl¯, and on the other hand, Chemicalbook drugs can open glutamate-controlled chloride ion channels. Increased Cl¯ permeability leads to hyperpolarization of the membrane potential, thus blocking the conduction of nerve signals and causing rapid, lethal and non-spastic neuromuscular paralysis and death of the worm.
03.Since flukes and tapeworms do not have GABA neurotransmitter and glutamate-controlled Cl¯ channels, these drugs have no repellent effect on them. The drug binding site of invertebrates is Chemicalbook in peripheral tissues, while the drug binding site of mammals is in the central nervous system. Due to the effect of the blood-brain barrier, such drugs can rarely enter the brain tissue, so such drugs are safe for most mammals.
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