| Customization: | Available |
|---|---|
| Varieties: | Antibiotic |
| Component: | Chemical Synthetic Drugs |
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| Product name | Gamithromycin | |
| CAS No. | 145435-72-9 | |
| MF | C40H76N2O12 | |
| MW | 777.05 | |
| EINECS | 604-472-4 |
Features:
Like other macrolide antibiotics, gamimycin inhibits peptide chain extension by binding to the 50S subunit of the ribosomes of sensitive bacteria, affecting the synthesis of bacterial proteins, thus playing a antibacterial and bactericidal role. Gamimycin mainly acts on pathogenic bacteria such as Mantella hemolyticus, Pasteurella multocida and histoma somnophila which cause respiratory diseases in cattle. In addition, Mycoplasma filamentum, Streptococcus equi epizoosis, Rhodococcus equi resistant to macrolides and sensitive to macrolides, mycoplasma suis and actinobacillus pleuropneumoniae, the pathogens of bovine chemicalbook-infected pleuropneumoniae, all showed good antibacterial activity in vitro. Gamimycin has good bacteriostasis and bactericidal effects on the main pathogens causing respiratory diseases in cattle
Description:
Pharmacokinetic studies in cattle, sheep, pigs, broilers, horses and other animals show that after subcutaneous or intramuscular injection, the drug is quickly absorbed, widely distributed, has a special affinity for lung tissue, bioavailability is nearly 100%, the effective drug concentration is maintained for a long time, and the elimination is slow. The plasma protein binding rates of gamimycin were 26.0%, 23.1%, 21.8% and 21.5% in cattle, pig, rat and dog, respectively.
The metabolites in different animals are not the same, but the metabolic pathways in rats, dogs and cattle are similar, mainly excreting the original drug through feces, followed by urine. The effective concentration in bovine lung epithelial cell lining fluid (PELF), bronchoalveolar lavage (BAL) cells and lung tissue was maintained for 7 (PELF) ~ 15 days. On day 1, 5, 10 and 15 after gamamycin administration, the ratio of concentrations in lung tissue to plasma was 265, 410, 329 and 247, respectively. The AUC in lung was 194 times higher than that in plasma, and the half-life in lung tissue was up to 90.4h.
Use:
It is mainly used to prevent and treat respiratory diseases of non-lactating cattle caused by pathogenic bacteria such as Mantella hemolyticus, Pasteurella and histophila.
1. Bovine application is used to treat bovine respiratory diseases (BRD) caused by sensitive bacteria.
2. The application of sheep is used to control hoof rot in sheep and to treat the sudden lameness of sheep caused by streptobacterin.
1.We have a professional and efficient team that can meet your various needs.
2.Have rich knowledge and sales experience in chemical products, and have in-depth research on the use of products and how to maximize their effects.
3.The system is sound, from supply to production, packaging, quality inspection, after-sales, and from quality to service to ensure customer satisfaction.
4.Price advantage. On the premise of ensuring quality, we will give you the best price to help maximize customers' interests.
5.Transportation advantages, air, sea, land, express, all have dedicated agents to take care of it. No matter what transportation method you want to take, we can do it.
Q1 Can i get some samples
A1 Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2 How to start orders or make payments
A2 Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T
Q3 How to confirm the Product Quality before placing orders
A3 You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q4 What's your MOQ
A4 Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5 How about delivery leadtime
A5 Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q6 Is there a discount
A6 Different quantity has different discount.
Q7 How do you treat quality complaint
A7 First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q8 How to contact us
A8 You can chat with us by Trademanager,MSN&Skype Online.
You can choose your interested products and send inquiry to us.
You can dial our telephone directly or send Email to us, you will get our reply.
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