Customization: | Available |
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Varieties: | Infectious Disease Prevention Medicine |
Component: | Chemical Synthetic Drugs |
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Common Name: Amoxicillin Trihydrate and Potassium Clavulanate 4:1.
Formula: Potassium Clavulanate: C8H8KNO5
Amoxicillin Trihydrate:C16H19N3O5S.3H2O
Molecular Weight: Potassium Clavulanate: 237.25 Amoxicillin Trihydrate:419.45
CAS: 61177-45-5
Specification: in-house
Description: Potassium clavulanate is a semi-synthetic beta-lactamase inhibitor isolated from Streptomyces. The compound contains a beta-lactam ring and strongly binds to beta-lactamase at their new active site, which protects other beta-lactam antibiotics such as amoxicillin from beta-lactamase catalysis.
Clavulanate is a β-lactamase inhibitor that is effective against Ambler class A β-lactamases (IC50 values range from 12 to 60 nM). While it is not an effective antibiotic by itself, clavulanate is commonly used with other antibiotics that would be inactivated by β-lactamases secreted by bacteria. It is often combined with amoxicillin and other penicillin-based antibiotics.
Use: Combination of potassium clavulanate and amoxicillin is normally used in medicine to treat numerous different infections caused by bacteria, for instance, pneumonia, sinusitis, ear infections, urinary tract infections, bronchitis, and skin infections. Potassium clavulanate can also combined with other penicillin-based antibiotics.
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