Animal Medicine Top Quality Maropitant Citrate CAS 147116-67-4
| Product Name |
Maropitant Citrate |
|
boiling point |
572.6±50.0 °C |
density |
1.11±0.1 g/cm3 |
| storage |
Store at -20°C |
| Valid time |
2 YEAR |
| Package |
10kg/Bottle, 20kg/Drum |
Description:
01.Maropitan citrate, also known as CJ-11,972 and marketed as Cerenia(antitonine), was originally developed by Pfizer. The molecular weight of Maropitant citrate is 678.82, and the chemical name is (2S, 3S) -2-diphenylmethyl-N -(5-tert-butyl-2-methoxybenzyl) -3-amino-quinine citrate monohydrate.
02.The synthesis method of maropitan was reported in the literature. The synthesis route of this method requires 8 steps to prepare the free base of Maropitant, which involves the Michael addition reaction involving the difficult to control phenylmagnesium bromide Chemicalbook reagent and Cuprous dimethyl sulfide bromide (CuBr•(CH)S), and the multi-step pressure hydrogenation reaction.
03.The above method of synthesizing maropitane free base not only has a long route and low yield (the total yield of the 8-step reaction is only about 10%), but also involves the use of a variety of precious metals, such as Ti, Pt, Pd, etc., which is not only costly, but also requires a lot of solvents and adsorbents to remove these precious metal residues. Therefore, the development of a new synthetic method of maropitane is particularly important for the industrial production of the drug.
Uses:
01.MaropitantCitrate is a receptor antibinding agent of neurokinin type 1 (NK1) that acts on the central nervous system by inhibiting Substance P, a key neurotransmitter that causes vomiting. Maropittan citrate is one of the alternative quinine drugs.
02.Due to its remarkable efficacy, the drug was approved by the FDA in 2007 for the prevention and treatment of acute vomiting in dogs, and was subsequently approved by Chemicalbook for off-prescription use in cats. Maropitant citrate has two dosage forms. Maropitant citrate for injection is used to prevent and treat acute vomiting in dogs.
03.Maropitan citrate tablets are used to prevent acute and vomiting due to motion sickness in dogs. Both are available as prescription medications for cats. The Chinese Ministry of Agriculture approved the import registration of Maropitan citrate in May 2016, which is also used to prevent and treat acute vomiting in dogs.
Q1 Can i get some samples
A1 Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2 How to start orders or make payments
A2 Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T
Q3 How to confirm the Product Quality before placing orders
A3 You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Q4 What's your MOQ
A4 Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5 How about delivery leadtime
A5 Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q6 Is there a discount
A6 Different quantity has different discount.
Q7 How do you treat quality complaint
A7 First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q8 How to contact us
A9 You can chat with us by Trademanager,Skype, Wechat, Whatsapp Online.
You can choose your interested products and send inquiry to us.
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JINAN ANDECHEM COMPANY LIMITED. Is a chemical product company integrating research and development, production, sales and service.
1.Chemical intermediates
2.Cosmetic Raw Materia
3.Amino Acid
4.Additives
5.Veterinary Drugs
6.Human API
7.Food additives
8.Finished cosmetic products
9.Others
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