CAS No.: | 7786-30-3 |
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Formula: | Mgcl2 |
EINECS: | 200-403-3, 232-094-6 |
Certification: | ISO |
Purity: | ≥99% |
Type: | Inorganic Chemicals, Magnesium Chloride |
Samples: |
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Customization: |
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Product Name: Hydrochlorothiazide
Packing: 25kg/drum
CAS: 58-93-5
MF: C7H8ClN3O4S2
MW: 297.74
Specification: USP
Uses:
The product is a typical representative in the thiazide diuretic drug with its pharmaceutical sales in United States ranking first in 1985. Owing to its easy administration, moderate action as well as being suitable for all kinds of edema, it is most often clinically applied. Owing to adverse reactions like potassium secretion, we should pay attention to supplement potassium salt during the application. Intravenous injection-mice-LD50: 590mg/kg, oral LD50: greater than 8000mg/kg.
Diuretics
It mainly inhibits the re-absorption on Na+ and Cl-by the proximal end of the distal convoluted tubule so that renal excretion of sodium chloride is increased to produce a diuretic effect. It is a kind of diuretic drugs of moderate effect. This product has antihypertensive effect with the effect being enhanced when being use in combination with Lee medicine paste, antihypertensive shen paste or apocynum venetum and other traditional Chinese medicine. This product also has anti-diuretic effect and can be used for the treatment of diabetes insipidus
Hydrochlorothiazide is one of the most widely used drugs of this series, and it is used for the same indications, as is chlorothiazide. Hydrochlorothiazide causes less inhibition of carbonic anhydrase, but causes 5-10 times more diuresis of sodium ions than chlorothiazide using the same dose.
Veterinary Drugs and Treatments:
In veterinary medicine, furosemide has largely supplanted the use of thiazides as a general diuretic (edema treatment). Thiazides are still used for the treatment of systemic hypertension, nephrogenic diabetes insipidus, and to help prevent the recurrence of calcium oxalate uroliths in dogs.
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